Developing Diverse Biopharmaceuticals with Light Scattering
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About The Event
From developability assessment to commercial manufacturing, the development of biopharmaceutical drug products entails multiple characterization challenges, made all the more complex when considering the range of diverse molecular formats from proteins to advanced therapy medicinal products (ATMPs).
Light scattering technologies provide key characterization tools that are key to addressing many of these challenges. Chief among these are multi-angle light scattering coupled to size-exclusion chromatography (SEC-MALS) and dynamic light scattering (DLS) performed without separation. Both techniques determine essential biophysical attributes in an absolute manner, rapidly and with no need for calibration against reference material or laborious sample preparation.
Following an introduction to light scattering technology and applications, this webinar will cover three case studies in the uses of SEC-MALS and DLS to characterize different types of biopharmaceuticals: antibodies, pegylated enzyme therapeutics and polyA-LNP. Attributes measured range from size and polydispersity, molar mass distribution and PEG-protein ratio to solution viscosity. These studies showcase the effectiveness of light scattering in supporting biopharmaceutical development towards successful commercialization.