Advancing Tau-opathy Research in PSP through High-Throughput and Predictive Analytics
January 23, 2025
11:00 AM EST / 08:00 AM PST
UPCOMING WEBINAR INFORMATION
Discover how high-throughput slide scanning and automated brain atlas registration enable a comprehensive, brain-wide assessment of tau pathology. This holistic platform, incorporating a machine learning model built by MetaCell, reveals predictive links between motor deficits and tau load in specific brain regions—laying the groundwork for uncovering connections between tau pathology and lesser-studied behavioral phenotypes. Join us for Dr. Creed's webinar to see how this workflow is driving her research forward. After the webinar, dive into educational content designed to help you bring this solution to your lab.
Towards a mechanistic understanding of how Tau pathology contributes to dysfunction in progressive supranuclear palsy
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with an estimated prevalence of 5-7 people in 100,000. Clinically characterized by impairments in gait, balance, and eye movements, as well as aggregated Tau pathology, PSP leads to death in approximately 5-8 years. No disease-modifying treatments are currently available. The contribution of Tau pathology to the symptoms of patients with PSP is poorly understood, in part due to lack of a rodent model that recapitulates characteristic aspects of PSP. Here, we assessed the hTau. P301S mouse for key clinical features of PSP, finding progressive impairments in balance and gait coordination. Additionally, we found impairments in fast vertical eye movements, one of the most distinctive features of PSP. Across animals, we found that Tau pathology in motor control regions correlated with motor deficits. These findings highlight the utility of the hP301S mouse in modeling key aspects of PSP.
Collaborators
Collaborate with us to share your breakthroughs!
Through the BrAInsight Breakthroughs, we partner with scientists to drive innovative research and develop advanced workflows. No matter what stage your project is in, reach out to explore how we can collaborate to bring your imaging and analysis goals to life. Together, let’s showcase your breakthroughs and the workflows that made them possible, inspiring and empowering the neuroscience community.
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Last time on BrAInsight Breakthroughs, we partnered with Dr. Mehwish Anwer from the University of British Columbia to investigate traumatic brain injury by using whole, cleared brain imaging and 3D atlas registration
About MetaCell
MetaCell is a life science-focused software company composed of scientists and software engineers with deep domain expertise in computational neuroscience, molecular biology, data science, and enterprise-grade cloud software development. Their team acts as an innovation partner alongside your R&D team to design and implement novel solutions for aggregating, visualizing, analyzing, and simulating medical and biological data. Since 2011, MetaCell's solutions and products have been trusted by some of the world's leading academic institutions and largest pharmaceutical companies. From novel research tools to clinical decision support and software for devices, they are a trusted partner to a growing list of academic and industry organizations aiming to innovate and better understand their life science data.
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