See how AUC reports on key parameters for understanding compound-induced interactions.
Learn how rigorous global fitting of AUC data provides thermodynamic and kinetic insights.
Discover how hydrodynamic modeling, alongside AUC, can unlock structural understanding.
A paradigm shift: AUC as a multi-attribute platform method in targeted protein degradation
About the Event
Targeted protein degradation (TPD) has gained significant attention in drug discovery thanks to its unique mechanism of action — removing a target protein in an event-driven manner, unlike traditional occupancy-driven, inhibitor-based therapies. This is achieved by using small molecules, known as degraders or molecular glues, to bring together two proteins: a target protein and an E3 ubiquitin ligase. The result is the clearance of the target protein by the cell’s own degradation machinery.
A key step in this process is ternary complex formation (TCF) between the ligase, the degrader molecule, and the target protein. Analytical ultracentrifugation (AUC) is especially well-suited to evaluating this ternary complex formation, providing both mechanistic and structural insights.
This webinar will introduce AUC and how it can perform VATC – the Velocity Assay for Ternary Complex, and its ability to screen compounds. We will also discuss further analysis through global fitting.
In this session, you will:
Reserve your spot and explore the science driving the next generation of drug discovery.
2025-GBL-EN-108590-v1