Insights into Cancer Progression: From Single Cell to Spatial

The first presentation explores breast cancer progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) using high‑resolution spatial transcriptomics, revealing cell‑type–specific gene expression changes and tumor–microenvironment interactions at single‑cell resolution. The second delves into pancreatic cancer–associated cachexia, leveraging bulk and single‑cell transcriptomics in human and mouse tissues to uncover parallel programs of metabolic crisis, inflammation, and systemic cellular state reversion. Together, these studies demonstrate how integrated spatial and single‑cell transcriptomic strategies can illuminate cancer progression and systemic remodeling, opening new avenues for therapeutic discovery.

Key Takeaway: 

• Explain the difference between PIPseq for single cell sequencing and other single cell sequencing techniques
• Describe how spatial transcriptomics can be used to study breast cancer progression in tissue samples
• Discuss at the single cell level how pancreatic cancer leads to muscle loss
  
  
  

Who Should Attend:

• Scientists, Directors, Senior Directors, Professors, Associate Professors, Assistant Professors.
  
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The views and opinions expressed by the invited speakers are their own and do not necessarily reflect the views or positions of the AACR.