Esra Ayan

Koç University 

ABSTRACT

Streptavidin is the pragmatic protein of choice for better understanding both intramolecular and intermolecular interactions and for versatile use in biotechnological applications. Here we present two high-resolution apo-streptavidin structures at both ambient temperature (Apo-SFX; 1.7 Å; LCLS) and cryogenic temperatures (Apo-Cryo; 1.1 Å; SSRL). In this study, we present the new cooperative allosteric perspective, in which streptavidin binds to the substrate through water molecules characterized by a polar interaction network and mimics the substrate biotin.

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Email: esraayan20@ku.edu.tr