Alec Pitter

University of Buffalo

ABSTRACT

Liposome size and size distribution are important factors in drug delivery applications. Typical  preparation routes for liposomes consist of multi-step procedures that include post-synthetic  extrusion methods to ensure appropriate size and dispersion are achieved. These parameters  often need re-optimization so the nanoparticles can be considered medicinally applicable. The  microfluidic technique used allows for this classical production route to be condensed to a chip  in a reproducible manner that gives more control over the physical properties of liposomes. A  stream of lipids dissolved in alcohol is sheathed and hydrodynamically focused by two lateral  aqueous streams in a channel at the micron scale. The laminar flow conditions allow for diffusive  mixing at the fluid interface where the lipid molecules spontaneously self-assemble into vesicle  systems. The liposomal dispersions produced were characterized using Dynamic Light Scattering  where it was observed that homogeneity was achieved as polydispersity values fell into the  monodisperse range.

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Email: alecpitt@buffalo.edu