Metals play critical roles in biology, conferring unique reactivity, enabling challenging chemistry and redox reactions, and functioning as structural scaffolds. It has been estimated that 30-50% of all proteins bind a metal or metal cofactor. Synchrotron-based techniques enable experiments that measure and monitor metal active site geometry and protein structure, as well as permitting elemental analysis to probe exactly what metals are present in a sample. In the Metals in Structural Biology workshop we will emphasize the use of spectroscopic, X-ray crystallography, XFEL and cryo-EM methods to study metalloprotein structure and function.
Organizers:
Sarah Bowman, Hauptman Woodward Institute
Jennifer Bridwell-Rabb, University of Michigan
Jeney Wierman, SLAC/SSRL
Agenda:
8am - 10 AM Panel Discussion
Panelists:
- Doug Rees, California Institute of Technology
- Allen Orville, Diamond Lightsource
- Liliana Quintanar, Cinvestav
- Kelly Chacon, Reed College
- John Bacik, Cornell University