During the COVID pandemic in March 2020, SSRL resumed operations, under a minimum operations mode, to support critical COVID-19 related research.  This session will highlight some recent results that employed X-ray light source facilities to further our understanding COVID-19 and aid in the search for an effective vaccine or other treatments.

Organizers:

Aina Cohen, SLAC National Accelerator Laboratory/SSRL

Clyde Smith, SLAC National Accelerator Laboratory/SSRL

Agenda

8:00am Introduction: Support of COVID-19 research at SSRL

Aina Cohen, SLAC National Accelerator Laboratory/SSRL

8:15am Keynote Lecture

Structural evaluation of the neutralizing antibody response to SARS CoV-2 

Ian Wilson (The Scripps Research Institute)

9:00am  Keynote Lecture

Structural insights into the feline coronavirus drug GC376, which inhibits the main protease of SARS-CoV-2 and blocks virus replication  

M. Joanne Lemieux (University of Alberta) 

9:45am  Structures of human antibodies bound to the SARS-CoV-2 spike glycoprotein define correlates of antibody-mediated neutralization 

Christopher Barnes (California Institute of Technology) 

10:15am Break – 15 minutes

10:30am  Covid-19 Quarantine Related Changes in Particulate Matter Source and Speciation

Benjamin Bostick (Columbia University) 

11:00am  Molecular biomimicry of the SARS-CoV-2 virus and consequences for severe inflammation

Gerard Wong (University of California, Los Angeles) 

11:30am  Finding ligands for the Nsp3 Macrodomain of SARS-CoV-2?  

James Fraser (University of California, San Francisco)

12:00pm Follow up discussion

12:30pm Adjourn