Towards microRNA-based therapeutics in cancer
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ABOUT THE EVENT
In Gene Expression University, you will learn from experts in real-time PCR and RNA Sequencing. Whether you are new to these technologies or an experienced gene expression researcher, you will find topics that will provide you with a deeper understanding of best practices for producing quality results.
Towards microRNA-based therapeutics in cancer
Frank J. Slack, Ph.D.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression to control important aspects of development and metabolism, such as cell differentiation, apoptosis, and lifespan. Various microRNAs, including let-7, miR-34, miR-21, and miR-155 are implicated in human cancers. Specifically, human let-7 and miR-34 are poorly expressed or deleted in lung cancer, and their over-expression in lung cancer cells inhibits their growth. Further, let-7 and miR-34 regulate the expression of important oncogenes implicated in lung cancer, suggesting a mechanism for their involvement in cancer. We are studying the role of these genes in regulating proto-oncogene expression during development and cancer, and on using miRNAs to suppress tumorigenesis. In contrast, miR-21 and miR-155 are up-regulated in many cancer types. We are working on developing effective strategies to target these miRNAs as a novel anti-cancer approach. Lastly, we are examining the non-coding portions of the genome for mutations and variants that are likely to impact the cancer phenotype. In this context, we have successfully re-sequenced the 3’UTRome and microRNAome from cancer patients with a family history of cancer, to gain insights the role of these elements in different cancer types.
In this virtual seminar you will learn about:
- Properties and functions of microRNAs
- Roles for microRNAs in cancer
- Methods for detecting and studying microRNAs
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